Discovery and Targeting of RNA Regulatory Structures in Viral Pathogens

Anna Marie Pyle is Sterling Professor of Molecular, Cellular and Developmental Biology and Professor of Chemistry at Yale University. She has been a Howard Hughes Medical Institute Investigator since 1997. Dr. Pyle obtained her undergraduate degree in Chemistry from Princeton University and received her Ph.D. in Chemistry from Columbia University in 1990, where she worked with Professor Jacqueline K. Barton. Dr. Pyle was a postdoctoral fellow in the laboratory of Thomas Cech at the University of Colorado. Dr. Pyle formed her own research group in 1992 in the Department of Biochemistry and Molecular Biophysics at Columbia University Medical Center. In 2002, she moved to Yale University, where she leads a research group that specializes in structure and function of large RNA molecules and RNA remodeling enzymes. Dr. Pyle was the Chair of the YSB building committee, she has served on the University Budget Committee and as the Chair of the Biological Sciences Advisory Committee, while also serving as Instructor in Charge for Molecular Biology (MCDB200/700). 

In addition to her work at Yale, Dr. Pyle is co-Chair of the Science and Technology Steering Committee at Brookhaven National Labs, she is past-President of the RNA Society and serves on advisory boards for many scientific organizations, including the Max Planck Institute for Natural Sciences. She is the Co-Editor of Methods in Enzymology, she is the author of more than 220 publications, and she is the founder of three companies. The Pyle laboratory uses a diverse set of approaches, including cryo-electron microscopy, biochemistry, cell biology, and enzymology, to understand the biological function of complex RNA molecules and their complexes with drugs and proteins. Dr. Pyle has received numerous honors and awards including election to the National Academy of Sciences (2023), the RNA Society Lifetime Service Award (2022), the Yale Faculty Innovation Award (2022), and election to the American Academy of Arts and Sciences (2005).