Dr. Hur is a Professor in the Department of Biological Chemistry and Molecular Pharmacology and the Oscar M. Schloss Professor of Pediatrics at Harvard Medical School. Dr. Hur is also a Senior Investigator in the Program in Cellular & Molecular Medicine at Boston Children's Hospital, and a Howard Hughes Medical Institute (HHMI) investigator. The Hur lab investigates immune mechanisms for self vs non-self-discrimination and transcriptional regulation of T cell development. Her research on a family of viral RNA receptors, RIG-I-like receptors, has led to the discovery of key mechanistic principles in foreign nucleic acid sensing, particularly the role of nucleic acid-scaffolded protein multimerization and hierarchical signalosome assembly. More recently, her work on transcription factors governing T cell self-tolerance has revealed distinct multimeric assembly mechanisms that underlie cognate DNA recognition and transcriptional regulation. Dr. Hur has received numerous distinctions in her career, including selection as a Pew Scholar, receipt of the Vilcek Prize for Creative Promise in Biomedical Science, and receipt of the NIH Director’s Pioneer Award. She was recently elected to American Academy of Arts and Sciences and National Academy of Medicine.